cellular stress increases progressively with aging in mammalian tissues . 
1 cellular 3 increases
1 cellular 4 progressively
2 stress 3 increases
4 progressively 5 with
4 progressively 6 aging
6 aging 7 in
7 in 8 mammalian
8 mammalian 9 tissues
9 tissues 10 .

dementia is a growing concern due to the aging process of the western societies ..y 
1 dementia 2 is
1 dementia 4 growing
2 is 3 a
4 growing 10 process
5 concern 6 due
5 concern 7 to
7 to 8 the
7 to 10 process
8 the 9 aging
10 process 11 of
10 process 14 societies
11 of 13 western
11 of 14 societies
12 the 13 western
14 societies 15 ..y

one measure of cellular aging is the telomere ..y 
1 one 3 of
2 measure 3 of
3 of 4 cellular
3 of 5 aging
4 cellular 5 aging
5 aging 7 the
6 is 7 the
7 the 9 ..y
8 telomere 9 ..y

moisturizing of the skin is recognized as the first anti-aging skin care . 
1 moisturizing 3 the
1 moisturizing 5 is
2 of 3 the
3 the 4 skin
5 is 7 as
6 recognized 7 as
7 as 9 first
8 the 9 first
9 first 12 care
10 anti-aging 11 skin
10 anti-aging 12 care
12 care 13 .

telomere shortening is associated with the risk of many aging-related diseases ..y 
1 telomere 2 shortening
2 shortening 3 is
2 shortening 6 the
3 is 4 associated
3 is 5 with
4 associated 5 with
5 with 6 the
6 the 7 risk
7 risk 10 aging-related
8 of 9 many
8 of 10 aging-related
10 aging-related 11 diseases
11 diseases 12 ..y

aerobic exercise has been suggested to ameliorate aging-related decline in humans . 
1 aerobic 2 exercise
1 aerobic 5 suggested
2 exercise 3 has
3 has 4 been
5 suggested 8 aging-related
6 to 7 ameliorate
6 to 8 aging-related
7 ameliorate 8 aging-related
8 aging-related 9 decline
8 aging-related 10 in
10 in 11 humans
11 humans 12 .

the aging eye appears to be at considerable risk from oxidative stress . 
1 the 3 eye
1 the 6 be
2 aging 3 eye
3 eye 4 appears
4 appears 5 to
4 appears 6 be
6 be 9 risk
7 at 8 considerable
7 at 9 risk
9 risk 11 oxidative
9 risk 13 .
10 from 11 oxidative
12 stress 13 .

sedentary aging results in a diminished rapid cutaneous vasodilator response to local heating . 
1 sedentary 2 aging
1 sedentary 6 diminished
3 results 4 in
4 in 5 a
5 a 6 diminished
6 diminished 8 cutaneous
7 rapid 8 cutaneous
8 cutaneous 10 response
9 vasodilator 10 response
10 response 11 to
10 response 12 local
12 local 13 heating
13 heating 14 .

caloric restriction is widely used to study aging processes ..y 
1 caloric 3 is
1 caloric 5 used
2 restriction 3 is
4 widely 5 used
5 used 7 study
6 to 7 study
7 study 8 aging
8 aging 9 processes
9 processes 10 ..y

oxidative stress is widely thought to underpin many aging processes . 
1 oxidative 2 stress
1 oxidative 5 thought
2 stress 3 is
2 stress 4 widely
4 widely 5 thought
5 thought 6 to
6 to 8 many
7 underpin 8 many
8 many 9 aging
8 many 10 processes
9 aging 10 processes
10 processes 11 .

menopause is a sign of aging in the woman ..y 
1 menopause 2 is
2 is 3 a
2 is 4 sign
4 sign 5 of
4 sign 6 aging
5 of 6 aging
6 aging 7 in
7 in 8 the
7 in 10 ..y
8 the 9 woman

a multivariate logistic model was run for our global successful aging measure . 
1 a 3 logistic
1 a 4 model
2 multivariate 3 logistic
3 logistic 4 model
4 model 5 was
4 model 6 run
5 was 6 run
6 run 11 aging
7 for 8 our
8 our 9 global
8 our 10 successful
9 global 10 successful
10 successful 11 aging
11 aging 13 .
12 measure 13 .

the pathogenesis of aging-associated structural changes is not completely understood ..y 
1 the 2 pathogenesis
1 the 4 aging-associated
3 of 4 aging-associated
4 aging-associated 8 not
5 structural 6 changes
6 changes 7 is
7 is 8 not
8 not 10 understood
9 completely 10 understood
10 understood 11 ..y

there are a number of mechanisms suggested to explain age-related endothelial dysfunction . 
1 there 2 are
1 there 3 a
1 there 4 number
2 are 3 a
3 a 4 number
4 number 5 of
4 number 7 suggested
6 mechanisms 7 suggested
7 suggested 9 explain
8 to 9 explain
9 explain 10 age-related
9 explain 12 dysfunction
10 age-related 11 endothelial
12 dysfunction 13 .

there is consistent evidence for a central role of mitochondrial dysfunction in these pathologies ..y 
1 there 2 is
1 there 4 evidence
2 is 3 consistent
4 evidence 6 a
4 evidence 12 in
5 for 6 a
6 a 9 of
7 central 8 role
8 role 9 of
9 of 10 mitochondrial
10 mitochondrial 11 dysfunction
12 in 13 these
13 these 14 pathologies
13 these 15 ..y
14 pathologies 15 ..y

mitochondrial dysfunction is associated with age-related degenerative diseases . 
1 mitochondrial 2 dysfunction
1 mitochondrial 3 is
3 is 4 associated
3 is 6 age-related
5 with 6 age-related
6 age-related 8 diseases
7 degenerative 8 diseases
8 diseases 9 .

how mitochondrial dysfunction causes cell degeneration is not well understood ..y 
1 how 2 mitochondrial
1 how 7 is
2 mitochondrial 3 dysfunction
3 dysfunction 4 causes
5 cell 6 degeneration
6 degeneration 7 is
7 is 9 well
8 not 9 well
9 well 10 understood
10 understood 11 ..y

decreases in fa correlated well with neuropsychological dysfunction ..y 
1 decreases 3 fa
2 in 3 fa
3 fa 4 correlated
4 correlated 5 well
5 well 6 with
5 well 7 neuropsychological
7 neuropsychological 8 dysfunction
7 neuropsychological 9 ..y
8 dysfunction 9 ..y

akt inhibition either by chemical inhibitors or small interfering rnas induced telomere dysfunction ..y 
1 akt 5 chemical
2 inhibition 3 either
3 either 4 by
4 by 5 chemical
5 chemical 6 inhibitors
5 chemical 7 or
7 or 11 induced
8 small 9 interfering
8 small 10 rnas
10 rnas 11 induced
11 induced 12 telomere
11 induced 14 ..y
12 telomere 13 dysfunction
13 dysfunction 14 ..y

with age comes an increased risk for chronic mental health disorders ..y 
1 with 2 age
1 with 4 an
2 age 3 comes
4 an 8 chronic
5 increased 6 risk
6 risk 7 for
7 for 8 chronic
8 chronic 10 health
9 mental 10 health
10 health 11 disorders
10 health 12 ..y
11 disorders 12 ..y

the comparison of women who underwent bilateral oophorectomy with referent women provided evidence for a sizeable neuroprotective effect of estrogen before age [@number@] years ..y 
1 the 4 women
1 the 5 who
1 the 10 referent
2 comparison 3 of
3 of 4 women
5 who 6 underwent
5 who 7 bilateral
5 who 9 with
7 bilateral 8 oophorectomy
10 referent 13 evidence
10 referent 14 for
10 referent 19 of
11 women 12 provided
11 women 13 evidence
12 provided 13 evidence
14 for 15 a
14 for 16 sizeable
17 neuroprotective 18 effect
17 neuroprotective 19 of
18 effect 19 of
19 of 21 before
19 of 22 age
20 estrogen 21 before
22 age 24 years
22 age 25 ..y
24 years 25 ..y

evidence for cholinergic dysfunction in very early stages of neurodegeneration like mild cognitive impairment ( mci ) is inconclusive ..y 
1 evidence 4 dysfunction
1 evidence 8 stages
2 for 3 cholinergic
2 for 4 dysfunction
3 cholinergic 4 dysfunction
4 dysfunction 5 in
6 very 7 early
6 very 8 stages
8 stages 18 is
9 of 10 neurodegeneration
10 neurodegeneration 11 like
11 like 12 mild
11 like 18 is
13 cognitive 14 impairment
13 cognitive 17 )
13 cognitive 18 is
14 impairment 15 (
16 mci 17 )
18 is 20 ..y
19 inconclusive 20 ..y

there was no statistically significant age or gender effect ..y 
1 there 3 no
2 was 3 no
3 no 4 statistically
4 statistically 8 gender
5 significant 6 age
6 age 8 gender
7 or 8 gender
8 gender 9 effect
9 effect 10 ..y

slowing of movement with aging is inevitable . 
1 slowing 3 movement
2 of 3 movement
3 movement 5 aging
4 with 5 aging
5 aging 6 is
5 aging 7 inevitable
7 inevitable 8 .

fat transfer for the aging face is an increasingly popular method for facial rejuvenation . 
1 fat 3 for
1 fat 9 increasingly
2 transfer 3 for
3 for 5 aging
4 the 5 aging
5 aging 6 face
6 face 7 is
7 is 8 an
9 increasingly 10 popular
10 popular 12 for
10 popular 14 rejuvenation
11 method 12 for
12 for 13 facial
14 rejuvenation 15 .

the aging eye appears to be at considerable risk from oxidative stress . 
1 the 3 eye
1 the 6 be
2 aging 3 eye
3 eye 4 appears
4 appears 5 to
4 appears 6 be
6 be 9 risk
7 at 8 considerable
7 at 9 risk
9 risk 11 oxidative
9 risk 13 .
10 from 11 oxidative
12 stress 13 .

lactase gene expression declines with aging in the majority of humans worldwide ..y 
1 lactase 5 with
1 lactase 12 worldwide
2 gene 3 expression
2 gene 4 declines
3 expression 4 declines
4 declines 5 with
5 with 6 aging
5 with 7 in
8 the 9 majority
8 the 12 worldwide
9 majority 11 humans
10 of 11 humans
12 worldwide 13 ..y

reproductive cessation is perhaps the earliest aging phenotype that humans experience ..y 
1 reproductive 2 cessation
1 reproductive 5 the
2 cessation 3 is
2 cessation 4 perhaps
5 the 6 earliest
6 earliest 8 phenotype
6 earliest 9 that
7 aging 8 phenotype
8 phenotype 9 that
9 that 10 humans
10 humans 12 ..y
11 experience 12 ..y

the complex etiology of aging is a challenge to the researchers ..y 
1 the 2 complex
1 the 3 etiology
2 complex 3 etiology
3 etiology 4 of
3 etiology 8 challenge
4 of 5 aging
4 of 6 is
7 a 8 challenge
8 challenge 11 researchers
9 to 10 the
10 the 11 researchers
11 researchers 12 ..y

the brain aging process is not uniform ..y 
1 the 4 process
2 brain 3 aging
3 aging 4 process
4 process 6 not
5 is 6 not
6 not 7 uniform
7 uniform 8 ..y

osteoporosis in elderly men is becoming an important health issue with the aging society ..y 
1 osteoporosis 2 in
1 osteoporosis 6 becoming
1 osteoporosis 11 with
2 in 3 elderly
3 elderly 6 becoming
4 men 5 is
5 is 6 becoming
6 becoming 9 health
7 an 8 important
8 important 9 health
9 health 10 issue
11 with 12 the
12 the 13 aging
13 aging 14 society
14 society 15 ..y

late onset hypogonadism is a common condition in aging males . 
1 late 3 hypogonadism
1 late 4 is
2 onset 3 hypogonadism
3 hypogonadism 4 is
4 is 6 common
5 a 6 common
6 common 8 in
7 condition 8 in
8 in 9 aging
9 aging 10 males
9 aging 11 .
10 males 11 .

environmental factors are key triggers in timing endocrine aging with implications for eventual disease ..y 
1 environmental 4 key
2 factors 3 are
2 factors 4 key
3 are 4 key
4 key 6 in
4 key 13 eventual
5 triggers 6 in
7 timing 8 endocrine
8 endocrine 13 eventual
9 aging 11 implications
9 aging 12 for
9 aging 13 eventual
10 with 11 implications
11 implications 12 for
13 eventual 14 disease
13 eventual 15 ..y
14 disease 15 ..y

the effects of aging were determined by testing for linear trends using regression analysis . 
1 the 2 effects
1 the 4 aging
1 the 9 for
2 effects 3 of
2 effects 4 aging
3 of 4 aging
4 aging 5 were
5 were 6 determined
6 determined 7 by
6 determined 8 testing
6 determined 9 for
7 by 8 testing
9 for 15 .
10 linear 11 trends
11 trends 12 using
11 trends 14 analysis
11 trends 15 .
12 using 13 regression
14 analysis 15 .

it makes obvious that the stochastic mechanism of aging is incorrect . 
1 it 5 the
2 makes 3 obvious
2 makes 4 that
4 that 5 the
5 the 7 mechanism
6 stochastic 7 mechanism
7 mechanism 8 of
7 mechanism 9 aging
8 of 9 aging
9 aging 11 incorrect
10 is 11 incorrect
11 incorrect 12 .

diagnostic imaging techniques guided the decision to use the posterior episcleral buckling procedure . 
1 diagnostic 2 imaging
1 diagnostic 9 the
3 techniques 4 guided
4 guided 5 the
5 the 6 decision
6 decision 7 to
7 to 8 use
7 to 9 the
8 use 9 the
9 the 12 buckling
10 posterior 11 episcleral
11 episcleral 12 buckling
12 buckling 14 .
13 procedure 14 .

facelift is the cornerstone procedure for the rejuvenation of the aging face ..y 
1 facelift 3 the
1 facelift 5 procedure
2 is 3 the
3 the 4 cornerstone
5 procedure 8 rejuvenation
6 for 7 the
7 the 8 rejuvenation
8 rejuvenation 9 of
8 rejuvenation 11 aging
9 of 10 the
11 aging 13 ..y
12 face 13 ..y

positron emission tomography imaging has been used to compare resting brain glucose metabolism ..y 
1 positron 2 emission
1 positron 3 tomography
3 tomography 4 imaging
3 tomography 5 has
5 has 7 used
5 has 10 resting
6 been 7 used
7 used 8 to
8 to 9 compare
10 resting 14 ..y
11 brain 12 glucose
12 glucose 13 metabolism
13 metabolism 14 ..y

transgenerational telomere erosion is therefore the material basis of aging at the species level ..y 
1 transgenerational 2 telomere
1 transgenerational 10 aging
2 telomere 3 erosion
2 telomere 4 is
4 is 7 material
5 therefore 6 the
6 the 7 material
7 material 8 basis
7 material 10 aging
8 basis 9 of
10 aging 14 level
10 aging 15 ..y
11 at 12 the
12 the 13 species
12 the 14 level

menopause is a key point moment in the specific aging process of women ..y 
1 menopause 2 is
1 menopause 6 moment
2 is 3 a
2 is 4 key
3 a 4 key
4 key 5 point
6 moment 8 the
6 moment 12 of
7 in 8 the
9 specific 10 aging
10 aging 11 process
10 aging 12 of
12 of 13 women
13 women 14 ..y

maintaining optimal nutritional status is therefore crucial for aging in good health . 
1 maintaining 4 status
2 optimal 3 nutritional
2 optimal 4 status
4 status 5 is
4 status 9 aging
6 therefore 7 crucial
7 crucial 8 for
8 for 9 aging
9 aging 10 in
9 aging 12 health
10 in 11 good
12 health 13 .

antiaging medicine is nowadays an equivocal topic frequently used in geriatric medicine . 
1 antiaging 2 medicine
1 antiaging 7 topic
2 medicine 3 is
3 is 4 nowadays
4 nowadays 5 an
5 an 6 equivocal
7 topic 8 frequently
7 topic 9 used
9 used 10 in
9 used 12 medicine
10 in 11 geriatric
10 in 12 medicine
12 medicine 13 .

the ability of organisms to adapt to their environment during aging is altered ..y 
1 the 4 organisms
1 the 5 to
2 ability 3 of
2 ability 4 organisms
3 of 4 organisms
5 to 7 to
5 to 13 altered
6 adapt 7 to
8 their 9 environment
9 environment 11 aging
9 environment 13 altered
10 during 11 aging
11 aging 12 is
13 altered 14 ..y

erectile dysfunction is a common disorder among aging males . 
1 erectile 5 common
2 dysfunction 3 is
3 is 4 a
4 a 5 common
5 common 6 disorder
6 disorder 7 among
6 disorder 9 males
7 among 8 aging
8 aging 9 males
9 males 10 .

senescence is a form of cellular aging that limits the proliferative capacity of cells ..y 
1 senescence 4 form
1 senescence 7 aging
2 is 3 a
2 is 4 form
4 form 5 of
5 of 6 cellular
5 of 7 aging
7 aging 9 limits
7 aging 10 the
8 that 9 limits
9 limits 10 the
10 the 13 of
10 the 15 ..y
11 proliferative 12 capacity
11 proliferative 13 of
13 of 14 cells

the poor functional status of aging combat-exposed veterans is of particular concern ..y 
1 the 2 poor
1 the 3 functional
3 functional 7 combat-exposed
4 status 5 of
5 of 6 aging
6 aging 7 combat-exposed
7 combat-exposed 11 particular
8 veterans 9 is
9 is 10 of
9 is 11 particular
11 particular 12 concern
12 concern 13 ..y

molecular mechanisms underlying t-cell aging are beginning to be understood ..y 
1 molecular 4 t-cell
2 mechanisms 3 underlying
3 underlying 4 t-cell
4 t-cell 6 are
4 t-cell 7 beginning
5 aging 6 are
7 beginning 10 understood
8 to 9 be
9 be 10 understood
10 understood 11 ..y

doppler flow imaging has been the mainstay of diagnosis ..y 
1 doppler 3 imaging
2 flow 3 imaging
3 imaging 4 has
4 has 6 the
5 been 6 the
6 the 7 mainstay
6 the 8 of
7 mainstay 8 of
8 of 10 ..y
9 diagnosis 10 ..y

posterior vitreous detachment is a common phenomenon in the aging eye ..y 
1 posterior 5 a
2 vitreous 3 detachment
3 detachment 4 is
3 detachment 5 a
4 is 5 a
5 a 7 phenomenon
6 common 7 phenomenon
7 phenomenon 10 aging
8 in 9 the
9 the 10 aging
10 aging 12 ..y
11 eye 12 ..y

adult stem cell function declines during the aging process of an organism ..y 
1 adult 2 stem
1 adult 5 declines
2 stem 5 declines
3 cell 4 function
4 function 5 declines
5 declines 6 during
5 declines 7 the
6 during 7 the
7 the 8 aging
7 the 10 of
8 aging 9 process
10 of 11 an
11 an 12 organism
12 organism 13 ..y

late-onset hypogonadism is a relatively common conditions affecting the aging male . 
1 late-onset 2 hypogonadism
1 late-onset 3 is
1 late-onset 6 common
3 is 4 a
4 a 5 relatively
6 common 8 affecting
7 conditions 8 affecting
8 affecting 10 aging
9 the 10 aging
10 aging 12 .
11 male 12 .

aging is a complex physiological process that poses considerable conundrums to rapidly aging societies ..y 
1 aging 3 a
1 aging 6 process
1 aging 7 that
1 aging 14 societies
2 is 3 a
3 a 5 physiological
3 a 6 process
4 complex 5 physiological
7 that 9 considerable
8 poses 9 considerable
10 conundrums 11 to
11 to 12 rapidly
12 rapidly 14 societies
13 aging 14 societies
14 societies 15 ..y

benign prostatic hyperplasia is a major health concern for aging men . 
1 benign 2 prostatic
2 prostatic 6 major
3 hyperplasia 4 is
4 is 5 a
4 is 6 major
6 major 7 health
6 major 8 concern
7 health 8 concern
8 concern 9 for
8 concern 10 aging
9 for 10 aging
10 aging 11 men
10 aging 12 .
11 men 12 .

one of the main manifestations of vascular aging is the development of atherosclerotic lesions . 
1 one 13 atherosclerotic
2 of 3 the
2 of 4 main
4 main 5 manifestations
4 main 6 of
6 of 7 vascular
6 of 9 is
6 of 10 the
7 vascular 8 aging
8 aging 9 is
10 the 12 of
10 the 13 atherosclerotic
11 development 12 of
13 atherosclerotic 14 lesions
14 lesions 15 .

the consequences of short-duration intermittent exercise on heat storage with aging are unclear . 
1 the 2 consequences
1 the 3 of
1 the 4 short-duration
1 the 11 aging
2 consequences 3 of
3 of 4 short-duration
4 short-duration 8 heat
5 intermittent 7 on
6 exercise 7 on
7 on 8 heat
8 heat 9 storage
8 heat 10 with
9 storage 10 with
10 with 11 aging
11 aging 12 are
11 aging 14 .
13 unclear 14 .

human aging is associated with the deterioration of long-lived proteins ..y 
1 human 4 associated
2 aging 3 is
2 aging 4 associated
4 associated 5 with
4 associated 7 deterioration
5 with 6 the
7 deterioration 8 of
8 of 11 ..y
9 long-lived 10 proteins
10 proteins 11 ..y

the underlying mechanisms of aging-exacerbated effects remain unknown . 
1 the 4 of
2 underlying 3 mechanisms
3 mechanisms 4 of
4 of 5 aging-exacerbated
4 of 7 remain
6 effects 7 remain
7 remain 8 unknown
8 unknown 9 .

the biological aging process is commonly associated with increased risk of cardiovascular diseases . 
1 the 3 aging
1 the 6 commonly
2 biological 3 aging
4 process 5 is
5 is 6 commonly
6 commonly 9 increased
7 associated 8 with
7 associated 9 increased
9 increased 12 cardiovascular
10 risk 11 of
11 of 12 cardiovascular
12 cardiovascular 13 diseases
13 diseases 14 .

carotenoids can serve as marker substances for the complete antioxidative network of human skin ..y 
1 carotenoids 4 as
2 can 4 as
3 serve 4 as
4 as 10 antioxidative
5 marker 6 substances
6 substances 7 for
7 for 8 the
7 for 9 complete
8 the 9 complete
9 complete 10 antioxidative
10 antioxidative 13 human
11 network 12 of
12 of 13 human
13 human 14 skin
14 skin 15 ..y

lipids in the skin are the most diverse in the entire human body ..y 
1 lipids 2 in
1 lipids 4 skin
2 in 3 the
3 the 4 skin
4 skin 9 in
5 are 6 the
6 the 7 most
7 most 8 diverse
8 diverse 9 in
9 in 12 human
10 the 11 entire
11 entire 12 human
12 human 14 ..y
13 body 14 ..y

autologous human keratinocytes forming sheet grafts are approved as skin substitutes ..y 
1 autologous 2 human
1 autologous 5 sheet
2 human 3 keratinocytes
3 keratinocytes 4 forming
5 sheet 8 approved
6 grafts 7 are
7 are 8 approved
8 approved 10 skin
9 as 10 skin
10 skin 12 ..y
11 substitutes 12 ..y

the contribution of autophagy to age-related changes in the human skin is unclear ..y 
1 the 3 of
1 the 5 to
1 the 8 in
2 contribution 3 of
3 of 4 autophagy
3 of 5 to
5 to 8 in
6 age-related 7 changes
7 changes 8 in
8 in 9 the
9 the 10 human
9 the 11 skin
10 human 11 skin
11 skin 12 is
12 is 14 ..y
13 unclear 14 ..y

locally administered bh4 increases vasoconstriction through adrenergic mechanisms in aged human skin ..y 
1 locally 3 bh4
2 administered 3 bh4
3 bh4 4 increases
3 bh4 6 through
4 increases 5 vasoconstriction
6 through 8 mechanisms
6 through 9 in
7 adrenergic 8 mechanisms
9 in 11 human
10 aged 11 human
11 human 13 ..y
12 skin 13 ..y

the majority of patients with major depressive disorder suffer from significant executive dysfunctions . 
1 the 7 depressive
2 majority 3 of
3 of 4 patients
3 of 5 with
3 of 6 major
4 patients 5 with
6 major 7 depressive
7 depressive 9 suffer
7 depressive 10 from
8 disorder 9 suffer
10 from 11 significant
10 from 12 executive
11 significant 12 executive
12 executive 13 dysfunctions
13 dysfunctions 14 .

mild cognitive changes ( especially executive dysfunction ) have been documented in many studies as well ..y 
1 mild 10 been
2 cognitive 3 changes
3 changes 9 have
4 ( 6 executive
4 ( 9 have
5 especially 6 executive
6 executive 8 )
7 dysfunction 8 )
9 have 10 been
10 been 16 well
11 documented 12 in
12 in 13 many
13 many 14 studies
13 many 15 as
13 many 16 well
14 studies 15 as
16 well 17 ..y

our findings support the use of multifractal analysis to assess aging-related microvascular dysfunction ..y 
1 our 2 findings
1 our 3 support
1 our 5 use
1 our 9 to
3 support 4 the
4 the 5 use
5 use 6 of
7 multifractal 8 analysis
7 multifractal 9 to
9 to 10 assess
9 to 13 dysfunction
10 assess 11 aging-related
11 aging-related 13 dysfunction
12 microvascular 13 dysfunction
13 dysfunction 14 ..y

the same therapeutic modalities can be used to treat erectile dysfunction after radical prostatectomy ..y 
1 the 2 same
1 the 5 can
2 same 3 therapeutic
3 therapeutic 4 modalities
5 can 10 erectile
5 can 12 after
6 be 7 used
7 used 8 to
7 used 9 treat
7 used 10 erectile
8 to 9 treat
10 erectile 11 dysfunction
12 after 14 prostatectomy
13 radical 14 prostatectomy
14 prostatectomy 15 ..y

cardiovascular disease risk factors may be important correlates of age-related auditory dysfunction ..y 
1 cardiovascular 2 disease
1 cardiovascular 6 be
2 disease 3 risk
2 disease 5 may
3 risk 4 factors
3 risk 5 may
4 factors 5 may
6 be 8 correlates
7 important 8 correlates
8 correlates 9 of
9 of 10 age-related
9 of 12 dysfunction
10 age-related 11 auditory
11 auditory 12 dysfunction
12 dysfunction 13 ..y

endothelial dysfunction in essential hypertension is an independent predictor for future cardiovascular events ..y 
1 endothelial 3 in
1 endothelial 5 hypertension
2 dysfunction 3 in
3 in 4 essential
5 hypertension 6 is
5 hypertension 9 predictor
7 an 8 independent
8 independent 9 predictor
9 predictor 13 events
10 for 11 future
11 future 12 cardiovascular
11 future 13 events
13 events 14 ..y

the incidence of postoperative cognitive dysfunction was observed less often than expected ..y 
1 the 3 of
1 the 5 cognitive
2 incidence 3 of
3 of 4 postoperative
5 cognitive 6 dysfunction
5 cognitive 8 observed
6 dysfunction 7 was
8 observed 10 often
9 less 10 often
10 often 11 than
11 than 13 ..y
12 expected 13 ..y

anesthesia-related postoperative cognitive dysfunction ( pocd ) leads to morbidity in the elderly . 
1 anesthesia-related 2 postoperative
1 anesthesia-related 4 dysfunction
2 postoperative 3 cognitive
4 dysfunction 9 to
5 ( 6 pocd
6 pocd 7 )
6 pocd 8 leads
8 leads 9 to
9 to 12 the
10 morbidity 11 in
11 in 12 the
12 the 13 elderly
13 elderly 14 .

it has been implicated with dysfunction in primary cilia . 
1 it 4 implicated
2 has 3 been
2 has 4 implicated
3 been 4 implicated
4 implicated 6 dysfunction
5 with 6 dysfunction
6 dysfunction 7 in
6 dysfunction 8 primary
7 in 8 primary
8 primary 10 .
9 cilia 10 .

mitochondrial dysfunction is a common hallmark of ageing-related diseases involving neurodegeneration ..y 
1 mitochondrial 5 common
2 dysfunction 3 is
2 dysfunction 4 a
4 a 5 common
5 common 6 hallmark
5 common 9 diseases
6 hallmark 7 of
7 of 8 ageing-related
7 of 9 diseases
9 diseases 11 neurodegeneration
10 involving 11 neurodegeneration
11 neurodegeneration 12 ..y

the origin of this ovarian dysfunction is still debatable ..y 
1 the 2 origin
1 the 3 of
3 of 6 dysfunction
4 this 5 ovarian
5 ovarian 6 dysfunction
6 dysfunction 8 still
7 is 8 still
8 still 9 debatable
8 still 10 ..y
9 debatable 10 ..y

ventricular dysfunction is frequently encountered in fontan patients ..y 
1 ventricular 2 dysfunction
1 ventricular 3 is
3 is 5 encountered
4 frequently 5 encountered
5 encountered 7 fontan
6 in 7 fontan
7 fontan 8 patients
8 patients 9 ..y

lipid oxidation products that accumulate in aged tissues may generate protein dysfunction ..y 
1 lipid 2 oxidation
1 lipid 4 that
2 oxidation 3 products
4 that 9 may
5 accumulate 6 in
6 in 7 aged
7 aged 9 may
8 tissues 9 may
9 may 11 protein
10 generate 11 protein
11 protein 12 dysfunction
11 protein 13 ..y

low levels of tfam lead to first-phase oxphos dysfunction . 
1 low 2 levels
1 low 4 tfam
2 levels 3 of
4 tfam 5 lead
5 lead 6 to
6 to 7 first-phase
6 to 9 dysfunction
7 first-phase 8 oxphos
9 dysfunction 10 .

mitochondrial dysfunction plausibly underlies the aging-associated brain degeneration . 
1 mitochondrial 3 plausibly
1 mitochondrial 4 underlies
2 dysfunction 3 plausibly
4 underlies 5 the
5 the 6 aging-associated
6 aging-associated 8 degeneration
7 brain 8 degeneration
8 degeneration 9 .

erectile dysfunction ( ed ) is a common disorder among aging males . 
1 erectile 2 dysfunction
2 dysfunction 9 disorder
3 ( 4 ed
4 ed 7 a
5 ) 6 is
6 is 7 a
7 a 8 common
7 a 9 disorder
9 disorder 10 among
9 disorder 11 aging
10 among 11 aging
11 aging 12 males
12 males 13 .

the key event caused by wrn gene mutation is the dysfunction of telomeres . 
1 the 2 key
1 the 6 wrn
2 key 4 caused
3 event 4 caused
4 caused 5 by
5 by 6 wrn
6 wrn 7 gene
6 wrn 9 is
7 gene 8 mutation
9 is 10 the
9 is 12 of
10 the 11 dysfunction
12 of 13 telomeres
12 of 14 .
13 telomeres 14 .

telomere dysfunction in ws is closely correlated with abnormality in tumorigenesis . 
1 telomere 5 is
2 dysfunction 3 in
3 in 4 ws
4 ws 5 is
5 is 6 closely
6 closely 7 correlated
6 closely 9 abnormality
7 correlated 9 abnormality
8 with 9 abnormality
9 abnormality 10 in
10 in 11 tumorigenesis
10 in 12 .

the increased functional connectivity within the frontal network was associated with executive dysfunction ..y 
1 the 2 increased
2 increased 7 frontal
3 functional 4 connectivity
4 connectivity 5 within
5 within 6 the
6 the 7 frontal
7 frontal 12 executive
8 network 9 was
8 network 10 associated
10 associated 11 with
11 with 12 executive
12 executive 13 dysfunction
12 executive 14 ..y

our data suggest that presynaptic snare dysfunction forms part of the synaptopathology of ad . 
1 our 2 data
1 our 6 snare
1 our 13 of
2 data 6 snare
3 suggest 4 that
4 that 5 presynaptic
4 that 6 snare
6 snare 7 dysfunction
7 dysfunction 8 forms
8 forms 9 part
8 forms 10 of
9 part 10 of
10 of 12 synaptopathology
10 of 13 of
11 the 12 synaptopathology
13 of 14 ad
14 ad 15 .

cardiac autonomic dysfunction is a serious condition in the elder subjects ..y 
1 cardiac 2 autonomic
1 cardiac 3 dysfunction
3 dysfunction 7 condition
4 is 5 a
4 is 6 serious
5 a 6 serious
6 serious 7 condition
7 condition 8 in
7 condition 9 the
9 the 10 elder
10 elder 11 subjects
10 elder 12 ..y

presepsin concentrations were significantly increased in patients with kidney dysfunction . 
1 presepsin 3 were
1 presepsin 5 increased
2 concentrations 3 were
3 were 4 significantly
5 increased 6 in
5 increased 7 patients
7 patients 8 with
7 patients 9 kidney
8 with 9 kidney
9 kidney 10 dysfunction
10 dysfunction 11 .

there was a predominance of dysfunctional variants in cases compared to controls ..y 
1 there 6 dysfunctional
2 was 4 predominance
3 a 4 predominance
4 predominance 5 of
5 of 6 dysfunctional
6 dysfunctional 7 variants
6 dysfunctional 8 in
8 in 9 cases
8 in 10 compared
10 compared 12 controls
11 to 12 controls
12 controls 13 ..y

microalbuminuria is a marker of kidney dysfunction frequently related to an inflammatory event . 
1 microalbuminuria 2 is
1 microalbuminuria 5 of
2 is 3 a
3 a 4 marker
3 a 5 of
5 of 7 dysfunction
6 kidney 7 dysfunction
7 dysfunction 9 related
8 frequently 9 related
9 related 13 event
10 to 11 an
11 an 12 inflammatory
12 inflammatory 13 event
13 event 14 .

thyroid dysfunction is common in the general population especially in women . 
1 thyroid 2 dysfunction
2 dysfunction 3 is
2 dysfunction 5 in
3 is 4 common
4 common 5 in
5 in 9 especially
6 the 7 general
6 the 8 population
7 general 8 population
8 population 9 especially
9 especially 12 .
10 in 11 women
10 in 12 .

force to distance analysis demonstrated a dependence on age ..y 
1 force 5 demonstrated
2 to 3 distance
3 distance 4 analysis
4 analysis 5 demonstrated
5 demonstrated 7 dependence
6 a 7 dependence
7 dependence 8 on
8 on 9 age
9 age 10 ..y

the population ageing is a challenge for health professionals ..y 
1 the 3 ageing
2 population 3 ageing
3 ageing 6 challenge
4 is 5 a
5 a 6 challenge
6 challenge 9 professionals
7 for 8 health
8 health 9 professionals
9 professionals 10 ..y

exercise habit in middle age was associated with low prevalence of sarcopenia in older age . 
1 exercise 12 sarcopenia
2 habit 6 was
3 in 4 middle
4 middle 6 was
5 age 6 was
6 was 7 associated
6 was 8 with
8 with 11 of
8 with 12 sarcopenia
9 low 10 prevalence
10 prevalence 11 of
11 of 12 sarcopenia
12 sarcopenia 13 in
12 sarcopenia 15 age
13 in 14 older
15 age 16 .

recent advances of mobile technologies have made mobile devices a promising tool to manage patients ' own health status through services like telemedicine . 
1 recent 2 advances
1 recent 12 tool
1 recent 16 '
2 advances 3 of
2 advances 6 have
3 of 5 technologies
4 mobile 5 technologies
6 have 7 made
8 mobile 9 devices
8 mobile 10 a
8 mobile 12 tool
10 a 11 promising
10 a 12 tool
12 tool 13 to
12 tool 14 manage
12 tool 15 patients
13 to 14 manage
14 manage 15 patients
15 patients 16 '
16 ' 18 health
16 ' 20 through
16 ' 24 .
17 own 18 health
18 health 19 status
20 through 21 services
20 through 24 .
21 services 22 like
22 like 23 telemedicine

multiple regression analysis was used to adjust for chronologic age ..y 
1 multiple 2 regression
2 regression 5 used
3 analysis 4 was
4 was 5 used
5 used 6 to
5 used 8 for
6 to 7 adjust
7 adjust 8 for
8 for 10 age
9 chronologic 10 age
10 age 11 ..y

asthma is a disease of all ages . 
1 asthma 2 is
1 asthma 3 a
3 a 6 all
4 disease 5 of
5 of 6 all
6 all 7 ages
7 ages 8 .

advancing age is associated with increased mortality even after controlling for preexisting morbidity . 
1 advancing 6 increased
2 age 3 is
3 is 5 with
4 associated 5 with
5 with 6 increased
6 increased 7 mortality
7 mortality 8 even
8 even 11 for
9 after 10 controlling
10 controlling 11 for
11 for 14 .
12 preexisting 13 morbidity
13 morbidity 14 .

old age vmrs are significantly enriched for neurotransmission pathways ..y 
1 old 2 age
1 old 5 significantly
2 age 3 vmrs
3 vmrs 4 are
5 significantly 6 enriched
6 enriched 7 for
7 for 8 neurotransmission
7 for 9 pathways
9 pathways 10 ..y

increased age is closely related with aforementioned alterations ..y 
1 increased 2 age
1 increased 4 closely
2 age 3 is
4 closely 5 related
4 closely 6 with
6 with 8 alterations
7 aforementioned 8 alterations
8 alterations 9 ..y

single-agent chemotherapy would be a good choice for elderly lung cancer ..y 
1 single-agent 2 chemotherapy
1 single-agent 6 good
2 chemotherapy 4 be
3 would 4 be
4 be 5 a
6 good 7 choice
7 choice 8 for
7 choice 9 elderly
8 for 9 elderly
9 elderly 10 lung
10 lung 11 cancer
11 cancer 12 ..y